Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TK2 | O00142 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6901491 | 0.90 | TK1 (0.43) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL21563929 | 0.88 | TK1 (0.43) | TK1LMNASMN1; SMN2TK2TYMS | |
| SCHEMBL6906785 | 0.81 | ADK (0.41) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL9443821 | 0.80 | RNASE1 (0.48) | TK1LMNASMN1; SMN2TK2CYP1A2 | |
| SCHEMBL21563855 | 0.80 | RNASE1 (0.48) | TK1LMNASMN1; SMN2TK2CYP1A2 | |
| SCHEMBL537189 | 0.80 | RNASE1 (0.48) | TK1LMNASMN1; SMN2TK2CYP1A2 | |
| SCHEMBL9470943 | 0.76 | LMNA (0.53) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL4728022 | 0.76 | TK1 (0.53) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL9470932 | 0.76 | LMNA (0.53) | TK1LMNASMN1; SMN2TK2ALOX12 | |
| SCHEMBL11144505 | 0.76 | LMNA (0.48) | TK1LMNASMN1; SMN2TK2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486477-A2 | 1-( -D-Arabinofuranosyl)-5-propynyluracil as a VZV-antiviral compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-05-20 | — | — | EP | disclosed |
| US-5079235-A | 5-Substituted Pyrimidine Nucleosides | BURROUGHS WELLCOME CO. (US) | 1992-01-07 | — | — | US | disclosed |
| EP-0417560-A1 | Antiviral compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-03-20 | — | — | EP | disclosed |
| EP-0272065-A2 | Antiviral compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1988-06-22 | — | — | EP | disclosed |