Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10449740 | 0.84 | SIGMAR1 (0.41) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL5854961 | 0.82 | SIGMAR1 (0.33) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL10568561 | 0.82 | RORC (0.44) | LMNAMAPTHSD17B1RECQLSMN1; SMN2 | |
| SCHEMBL9635181 | 0.81 | SIGMAR1 (0.40) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL9862665 | 0.79 | LMNA (0.42) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL5855210 | 0.78 | NMT2 (0.30) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL9862607 | 0.77 | FFAR1 (0.42) | — | |
| SCHEMBL5348869 | 0.76 | HTR2C (0.43) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL14569853 | 0.76 | HTR2C (0.43) | SIGMAR1ADRB2HTR1AADRA2AADRA2B | |
| SCHEMBL10594963 | 0.75 | ESR1 (0.38) | SIGMAR1ADRB2HTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166509-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-13 | — | — | EP | disclosed |
| US-4833135-A | Antioestrogenic phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-23 | — | — | US | disclosed |