Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 6/20 | 0.46 |
| ▸ | HRH2 | P25021 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635008 | 0.83 | SLC6A9 (0.55) | SLC6A9HRH1TP53ALDH1A1KMT2A | |
| SCHEMBL9685805 | 0.82 | SLC6A9 (0.61) | SLC6A9HRH1TP53ALDH1A1KMT2A | |
| SCHEMBL9538793 | 0.81 | NOS2 (0.48) | SLC6A9HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9634656 | 0.81 | FAAH (0.52) | SLC6A9HTR3EHTR3BHTR3AHTR3D | |
| Oxalic Acid SCHEMBL9870147 | 0.81 | SLC6A9 (0.66) | SLC6A9TP53KDM4EALDH1A1KMT2A | |
| Oxalic Acid SCHEMBL9870156 | 0.81 | SLC6A9 (0.66) | SLC6A9TP53KDM4EALDH1A1KMT2A | |
| SCHEMBL9686403 | 0.81 | SLC6A9 (0.60) | SLC6A9HRH1TP53ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL9634676 | 0.80 | SLC6A9 (0.56) | SLC6A9TP53ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL9634790 | 0.80 | SLC6A9 (0.55) | SLC6A9TP53ALDH1A1KMT2A | |
| SCHEMBL9536529 | 0.79 | NOS2 (0.55) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| US-5086056-A | Treating allergic diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-04 | — | — | US | disclosed |
| US-5011842-A | Antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-30 | — | — | US | disclosed |
| US-4946843-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-07 | — | — | US | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |