Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA7 | P43166 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635153 | 0.98 | CA5A (0.42) | CA5ACA12CA1CA2CA7 | |
| Iodide SCHEMBL11214733 | 0.82 | LMNA (0.42) | CA5ACA12CA1CA2CA7 | |
| SCHEMBL11020500 | 0.81 | CA12 (0.46) | CA12CA1CA2CA9FASN | |
| SCHEMBL5144207 | 0.80 | LMNA (0.44) | CA5ACA12CA1CA2CA7 | |
| Iodide SCHEMBL9636197 | 0.78 | KDM4E (0.54) | CA12CA1CA2CA7CA9 | |
| Iodide SCHEMBL10522536 | 0.77 | CES2 (0.49) | MAPT | |
| Iodide SCHEMBL2353850 | 0.76 | MDM2 (0.47) | CA5ACA12CA1CA2CA7 | |
| SCHEMBL11021523 | 0.76 | KDM4E (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2221653 | 0.74 | MDM2 (0.48) | CA5ACA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL2356480 | 0.73 | MDM2 (0.47) | CA5ACA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0241915-B1 | METHOD FOR DETERMINING CHOLINESTERASE ACTIVITY | NITTO BOSEKI CO., LTD. (JP) | 1992-07-08 | — | — | EP | claimed |
| US-4861713-A | Novel method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1989-08-29 | — | — | US | claimed |
| EP-0241915-A1 | Method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1987-10-21 | — | — | EP | claimed |
| JP-62244397-A | — | — | None | — | — | JP | disclosed |
| EP-0241915-B1 | METHOD FOR DETERMINING CHOLINESTERASE ACTIVITY | NITTO BOSEKI CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |
| US-4861713-A | Novel method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| JP-S62244397-A | NOVEL MEASUREMENT OF CHOLINE ESTERASE ACTIVITY | NITTO BOSEKI CO LTD | 1987-10-24 | — | — | JP | disclosed |
| EP-0241915-A1 | Method for determining cholinesterase activity | NITTO BOSEKI CO., LTD. (JP) | 1987-10-21 | — | — | EP | disclosed |