Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772386 | 0.85 | TP53 (0.51) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL9634894 | 0.79 | SLC6A9 (0.53) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL9691446 | 0.78 | TSHR (0.48) | LMNATP53KMT2A | |
| SCHEMBL16768160 | 0.78 | GAA (0.51) | LMNATP53MEN1KMT2AMAPT | |
| SCHEMBL9634955 | 0.77 | CHRM5 (0.57) | LMNAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL9540969 | 0.77 | LMNA (0.46) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL29111000 | 0.73 | LMNA (0.40) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL9635952 | 0.73 | LMNA (0.45) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL29491420 | 0.73 | LMNA (0.40) | LMNATBXA2RTP53ENPP2MEN1 | |
| SCHEMBL9538036 | 0.73 | CCR3 (0.48) | LMNATP53ENPP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| US-5086056-A | Treating allergic diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-04 | — | — | US | disclosed |
| US-5011842-A | Antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-30 | — | — | US | disclosed |
| US-4946843-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-07 | — | — | US | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |