Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | EPX | P11678 | 1/20 | 0.36 |
| ▸ | LPO | P22079 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10610427 | 0.87 | CYP3A4 (0.42) | CYP3A4TSHRGRM4CYP1A2CYP2C19 | |
| SCHEMBL631806 | 0.81 | ALDH1A1 (0.52) | CYP3A4TSHRGRM4CYP1A2ALDH1A1 | |
| SCHEMBL17050467 | 0.81 | KDM4E (0.43) | CYP3A4TSHRGRM4ALDH1A1MPO | |
| SCHEMBL9770766 | 0.81 | CYP1A2 (0.47) | CYP3A4CYP1A2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL17050472 | 0.78 | HPGD (0.48) | CYP3A4CYP1A2CYP2C19ALDH1A1KMT2A | |
| SCHEMBL10506972 | 0.77 | GAA (0.42) | TSHRALDH1A1KMT2AGAAPOLB | |
| SCHEMBL1964539 | 0.76 | CYP3A4 (0.56) | CYP3A4TSHRALDH1A1KMT2AGAA | |
| SCHEMBL10495488 | 0.75 | RET (0.35) | CYP3A4TSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL27273576 | 0.75 | ALDH1A1 (0.56) | CYP3A4GRM4CYP1A2ALDH1A1KMT2A | |
| SCHEMBL22069698 | 0.75 | MAPT (0.57) | CYP3A4TSHRCYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0192235-B1 | BENZOYL UREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION, AND ANTITUMOROUS COMPOSITIONS CONTAINING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1989-11-23 | — | — | EP | claimed |
| EP-0192235-A1 | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1986-08-27 | — | — | EP | claimed |
| EP-0192263-B1 | READILY ABSORBABLE PHARMACEUTICAL COMPOSITION | ISHIHARA SANGYO KAISHA LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4987135-A | Leukemia, melanoma | ISHIHARA SANGYO KAISHA LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| EP-0192235-B1 | BENZOYL UREA COMPOUNDS, PROCESS FOR THEIR PRODUCTION, AND ANTITUMOROUS COMPOSITIONS CONTAINING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1989-11-23 | — | — | EP | disclosed |
| EP-0335408-A2 | Substituted benzene derivatives, processes for their production and antitumour compositions containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4849425-A | ANTITUMOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| US-4727077-A | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| EP-0192235-A1 | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1986-08-27 | — | — | EP | disclosed |
| EP-0192263-A2 | Readily absorbable pharmaceutical composition | ISHIHARA SANGYO KAISHA LTD. (JP) | 1986-08-27 | — | — | EP | disclosed |