Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCND3 | P30281 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7272073 | 0.86 | KDM4E (0.39) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL10734983 | 0.84 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL7281864 | 0.84 | AMY1A (0.57) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL9635793 | 0.82 | ACHE (0.45) | AMY1AKDM4EPDE5APDE3BPDE3A | |
| SCHEMBL7270979 | 0.81 | ALOX5 (0.51) | CDK2KDM4EGAANPSR1PDE5A | |
| SCHEMBL9636036 | 0.81 | AMY1A (0.39) | AMY1AKDM4EGAANPSR1MGAM | |
| Hydrochloric Acid SCHEMBL10845977 | 0.80 | PDE5A (0.50) | CDK2KDM4EGAANPSR1PDE5A | |
| SCHEMBL9636239 | 0.80 | CBFB (0.44) | KDM4ENPSR1PDE5APDE3BPDE3A | |
| SCHEMBL7282149 | 0.80 | CDK4 (0.56) | CDK4CCNA2CCND1CDK2CCND3 | |
| Hydrochloric Acid SCHEMBL10847852 | 0.80 | PDE5A (0.39) | AMY1AKDM4EGAANPSR1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |