Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MGMT | P16455 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693715 | 0.84 | CYP1A2 (0.52) | L3MBTL1ALDH1A1KDM4EPKMCYP3A4 | |
| SCHEMBL5159572 | 0.84 | CYP1A2 (0.52) | L3MBTL1ALDH1A1KDM4EPKMCYP3A4 | |
| SCHEMBL460266 | 0.82 | ALDH1A1 (0.63) | L3MBTL1ALDH1A1KDM4EPKMTSHR | |
| SCHEMBL11776814 | 0.80 | MAPT (0.63) | ALDH1A1KDM4EPKMTDP1RECQL | |
| SCHEMBL11425242 | 0.80 | ALDH1A1 (0.56) | ALDH1A1CYP3A4TSHRMAPK1LMNA | |
| SCHEMBL1351968 | 0.80 | ALDH1A1 (0.62) | L3MBTL1ALDH1A1CYP3A4ALOX15TDP1 | |
| SCHEMBL29389163 | 0.80 | ALDH1A1 (0.62) | L3MBTL1ALDH1A1CYP3A4ALOX15TDP1 | |
| SCHEMBL8391800 | 0.77 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL17728707 | 0.77 | ALDH1A1 (0.48) | L3MBTL1ALDH1A1KDM4EPKMCYP3A4 | |
| SCHEMBL9636348 | 0.76 | HTT (0.53) | L3MBTL1ALDH1A1KDM4EPKMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303232-B1 | USE OF BENZYLPYRIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DEMENTIA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4851414-A | AMIDO NITRO BENZYLPYRIDINES | KYOWA HAKKO KAGYO CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| EP-0303232-A2 | Use of benzylpyridine derivatives in the manufacture of a medicament for the treatment of dementia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |