SCHEMBL9636484

SCHEMBL9636484

Cc1ccc2c(c1C)N(Cc1ccccc1)C(C)(C)CC2C

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AMPD2 Q01433 8/20 0.44
MAPT P10636 2/20 0.42
LMNA P02545 3/20 0.37
NPSR1 Q6W5P4 2/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
DRD2 P14416 1/20 0.35
DRD4 P21917 1/20 0.35
ACHE P22303 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
KIF11 P52732 1/20 0.35
SLC6A3 Q01959 1/20 0.35
TP53 P04637 1/20 0.34
HTT P42858 1/20 0.34
OPRM1 P35372 1/20 0.34
OPRD1 P41143 1/20 0.34
OPRK1 P41145 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11784247 0.88 AMPD2 (0.50) AMPD2MAPTLMNANPSR1MEN1
SCHEMBL9636472 0.78 AMPD2 (0.42) AMPD2MAPTLMNANPSR1MEN1
SCHEMBL9847602 0.77 DRD2 (0.49) AMPD2MAPTLMNANPSR1MEN1
SCHEMBL9073520 0.77 AMPD2 (0.49) AMPD2LMNADRD2DRD4
SCHEMBL11783355 0.75 DRD2 (0.46) AMPD2LMNANPSR1DRD2DRD4
SCHEMBL21452893 0.74 GAA (0.45) AMPD2LMNAMEN1KMT2A
SCHEMBL11782496 0.72 SIGMAR1 (0.45) AMPD2MAPTNPSR1MEN1KMT2A
SCHEMBL31476440 0.72 AMPD2 (0.39) AMPD2LMNANPSR1MEN1KMT2A
SCHEMBL11783262 0.71 AMPD2 (0.50) AMPD2LMNAMEN1KMT2ADRD2
SCHEMBL25329514 0.69 DRD2 (0.46) AMPD2LMNANPSR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273868-B1 N-SUBSTITUTED TETRAHYDROQUINOLINES AS ANTIOXIDANTS FOR LUBRICANTS CIBA-GEIGY AG (CH) 1992-07-08 EP disclosed