Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9637483 | 0.98 | HSD17B10 (0.37) | HPGDSMN1; SMN2HSD17B10TSHRPTPN1 | |
| SCHEMBL9637680 | 0.83 | IKBKB (0.37) | HPGDSMN1; SMN2HSD17B10TSHRMAPT | |
| SCHEMBL9637671 | 0.83 | HPGD (0.34) | HPGDSMN1; SMN2HSD17B10TSHRMAPT | |
| SCHEMBL9637450 | 0.82 | HPGD (0.46) | HPGDSMN1; SMN2HSD17B10TSHRMAPT | |
| SCHEMBL9637422 | 0.75 | L3MBTL1 (0.55) | SMN1; SMN2TSHRMAPTRAB9AALDH1A1 | |
| SCHEMBL16986063 | 0.69 | GPR35 (0.38) | HPGDTSHRPTPN1KDM4EGPR35 | |
| SCHEMBL30852499 | 0.69 | CDC7 (0.44) | HPGDSMN1; SMN2HSD17B10TSHRMAPT | |
| SCHEMBL12768618 | 0.69 | GPR35 (0.41) | HPGDSMN1; SMN2TSHRPTPN1KDM4E | |
| SCHEMBL21939302 | 0.66 | HSD11B1 (0.47) | HPGDSMN1; SMN2HSD17B10TSHRMAPT | |
| SCHEMBL17871026 | 0.65 | GPR35 (0.36) | PTPN1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171860-A | Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors | MERCK & CO., INC. (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0067436-B1 | DIAMINO ISOTHIAZOLE -1-OXIDES AND -1,1-DIOXIDES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0067436-A2 | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |