Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11231869 | 0.98 | L3MBTL1 (0.41) | L3MBTL1PRMT6CYP1A2CYP3A4CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL9637644 | 0.78 | TYR (0.31) | — | |
| SCHEMBL11315005 | 0.76 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL3291349 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL11478924 | 0.74 | L3MBTL1 (0.53) | L3MBTL1PRMT6CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11089815 | 0.74 | SMN1; SMN2 (0.36) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Benzene SCHEMBL7660246 | 0.73 | ALDH1A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL25323764 | 0.72 | — | — | |
| SCHEMBL11326422 | 0.71 | ACHE (0.39) | L3MBTL1 | |
| SCHEMBL11643707 | 0.71 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171860-A | Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors | MERCK & CO., INC. (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0040696-B1 | AMINOTHIADIAZOLES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-08-27 | — | — | EP | disclosed |
| EP-0067436-B1 | DIAMINO ISOTHIAZOLE -1-OXIDES AND -1,1-DIOXIDES AS GASTRIC SECRETION INHIBITORS | MERCK & CO. INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| US-4440775-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-03 | — | — | US | disclosed |
| EP-0067436-A2 | Diamino isothiazole -1-oxides and -1,1-dioxides as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |
| US-4347250-A | ANTIHISTAMINES; ANTISECRETORY, CARDIOTONIC, AND ANTI-INFLAMMATORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-08-31 | — | — | US | disclosed |
| US-4333946-A | ANTIINFLAMMATORY AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-06-08 | — | — | US | disclosed |
| US-4317829-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-03-02 | — | — | US | disclosed |
| US-4307101-A | ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-22 | — | — | US | disclosed |
| EP-0040696-A2 | Aminothiadiazoles as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | disclosed |
| US-4166856-A | Thiazole and isothiazole derivative as blockers of histamine H2 -receptors | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-09-04 | — | — | US | disclosed |
| US-4153704-A | HETEROCYCLIC-ALKYL-AMINO SUBSTITUTED, ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-08 | — | — | US | disclosed |
| US-4151288-A | ANTHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-04-24 | — | — | US | disclosed |
| US-4137234-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-01-30 | — | — | US | disclosed |
| US-4124717-A | INHIBITORS OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-11-07 | — | — | US | disclosed |
| US-4098898-A | N-SUBSTITUTED-N'-HETEROCYCLIC ALKYLTHIOUREAS, GUANIDINES, AND ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-07-04 | — | — | US | disclosed |
| US-4080459-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-03-21 | — | — | US | disclosed |
| US-4018931-A | INHIBITION OF H-2 HISTAMINE RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-04-19 | — | — | US | disclosed |
| US-4013769-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-03-22 | — | — | US | disclosed |
| US-3950353-A | HISTAMINE INHIBITORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-04-13 | — | — | US | disclosed |