Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | BCL9 | O00512 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907507 | 0.82 | LMNA (0.61) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL11500222 | 0.81 | KMT2A (0.50) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL9056871 | 0.81 | KMT2A (0.50) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL22265096 | 0.81 | KMT2A (0.56) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL329955 | 0.80 | ALDH1A1 (0.49) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL7911559 | 0.80 | KMT2A (0.63) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL29176175 | 0.80 | KMT2A (0.44) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL15501169 | 0.79 | HSD17B10 (0.58) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL5799142 | 0.79 | RAB9A (0.53) | KMT2ALMNAMAPTALDH1A1HTT | |
| SCHEMBL2703212 | 0.78 | ALDH1A1 (0.47) | KMT2ALMNAMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367508-B1 | MERCAPTOALKYL ACETOACETATES, USE THEREOF AND A PROCESS FOR THE PREPARATION OF MERCAPTOALKYL ACETOACETATES | ROHM AND HAAS COMPANY (US) | 1992-07-22 | — | — | EP | disclosed |
| US-4960924-A | Mercaptoalkyl acetoacetates | ROHM AND HAAS COMPANY (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0367508-A1 | Mercaptoalkyl acetoacetates, use thereof and a process for the preparation of mercaptoalkyl acetoacetates | ROHM AND HAAS COMPANY (US) | 1990-05-09 | — | — | EP | disclosed |