Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.32 |
| ▸ | PPARA | Q07869 | 4/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9593810 | 0.99 | LMNA (0.33) | LMNAMAPK1HTTL3MBTL1NPC1 | |
| SCHEMBL9641212 | 0.87 | HRH3 (0.34) | MAPTALDH1A1S1PR3GAA | |
| Bromide SCHEMBL9595283 | 0.86 | HRH3 (0.33) | MAPTALDH1A1S1PR3GAA | |
| SCHEMBL9640334 | 0.83 | CYP2D6 (0.35) | LMNAMAPK1SMN1; SMN2MAPTALDH1A1 | |
| Bromide SCHEMBL9595609 | 0.82 | CYP2D6 (0.35) | LMNAMAPK1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL27814642 | 0.77 | LMNA (0.43) | LMNAL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9641429 | 0.76 | — | — | |
| SCHEMBL9640312 | 0.75 | TSHR (0.34) | HTTL3MBTL1 | |
| Bromide SCHEMBL9595302 | 0.74 | TSHR (0.33) | HTTL3MBTL1 | |
| Iodide SCHEMBL9593224 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288394-B1 | 1,2,5,6-TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |
| EP-0288394-A2 | 1,2,5,6-Tetrahydropyridines, process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-26 | — | — | EP | disclosed |