Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9595302 | 0.99 | TSHR (0.33) | TSHRMEN1KMT2AATMPOLB | |
| SCHEMBL9640334 | 0.83 | CYP2D6 (0.35) | TSHRMEN1KMT2APOLBSIGMAR1 | |
| Bromide SCHEMBL9595609 | 0.82 | CYP2D6 (0.35) | TSHRMEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL27814642 | 0.77 | LMNA (0.43) | TSHRKMT2APOLBL3MBTL1 | |
| SCHEMBL2805436 | 0.77 | CCR2 (0.39) | TSHRMEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL9640355 | 0.75 | LMNA (0.34) | HTTL3MBTL1 | |
| SCHEMBL9641212 | 0.75 | HRH3 (0.34) | TSHRMEN1KMT2ASIGMAR1 | |
| SCHEMBL6700044 | 0.75 | KDM4E (0.40) | — | |
| SCHEMBL2353804 | 0.74 | PARP1 (0.40) | MEN1KMT2A | |
| SCHEMBL5673745 | 0.74 | BRD4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288394-B1 | 1,2,5,6-TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |
| EP-0288394-A2 | 1,2,5,6-Tetrahydropyridines, process for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-26 | — | — | EP | disclosed |