Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641212 | 0.99 | HRH3 (0.34) | HRH3GAASIGMAR1CRHBPCRHR2 | |
| SCHEMBL9640355 | 0.86 | LMNA (0.34) | GAAALDH1A1MAPTS1PR3 | |
| Bromide SCHEMBL9595609 | 0.85 | CYP2D6 (0.35) | GAASIGMAR1CYP2D6ALDH1A1MAPT | |
| SCHEMBL9640334 | 0.84 | CYP2D6 (0.35) | GAASIGMAR1CYP2D6ALDH1A1MAPT | |
| SCHEMBL27814642 | 0.78 | LMNA (0.43) | CYP2D6ALDH1A1TSHRKMT2A | |
| Bromide SCHEMBL9595302 | 0.75 | TSHR (0.33) | SIGMAR1TSHRMEN1KMT2A | |
| SCHEMBL2805436 | 0.75 | CCR2 (0.39) | GAASIGMAR1CYP2D6ALDH1A1TSHR | |
| SCHEMBL9640312 | 0.74 | TSHR (0.34) | SIGMAR1TSHRMEN1KMT2A | |
| Trichloroacetic Acid SCHEMBL27834532 | 0.73 | LMNA (0.39) | CYP2D6ALDH1A1TSHRKMT2A | |
| SCHEMBL2353804 | 0.72 | PARP1 (0.40) | GAACYP2D6ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219873-A | Treating Alzheimer*s disease, memory disorders | ROUSSEL UCLAF (FR) | 1993-06-15 | — | — | US | disclosed |