Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.43 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | LDHB | P07195 | 2/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641940 | 0.92 | AKR1B1 (0.41) | AKR1B1LDHALDHBFASNALDH1A1 | |
| SCHEMBL9642684 | 0.90 | AKR1B1 (0.42) | AKR1B1LDHALDHBFASNALDH1A1 | |
| SCHEMBL9643120 | 0.83 | AKR1B1 (0.37) | AKR1B1LDHALDHBFASNALDH1A1 | |
| SCHEMBL9642125 | 0.82 | THRA (0.43) | AKR1B1LDHALDHB | |
| SCHEMBL9641584 | 0.81 | ABCB11 (0.54) | AKR1B1LDHALDHBALDH1A1KDM4E | |
| SCHEMBL9643555 | 0.81 | ALDH1A1 (0.44) | AKR1B1ALDH1A1KMT2AKDM4EGLA | |
| SCHEMBL9642103 | 0.81 | ABCB11 (0.58) | ALDH1A1KMT2AKDM4EGLAGAA | |
| SCHEMBL9643387 | 0.81 | ABCB11 (0.58) | ALDH1A1KMT2AKDM4EGLAGAA | |
| SCHEMBL9641729 | 0.78 | ABCB11 (0.37) | AKR1B1LDHALDHBKMT2AGAA | |
| SCHEMBL9643480 | 0.77 | ABCB11 (0.36) | AKR1B1ALDH1A1KMT2AKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |