Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 5/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641940 | 0.89 | AKR1B1 (0.41) | AKR1B1LDHALDHB | |
| SCHEMBL9641694 | 0.88 | THRA (0.39) | THRATHRBAKR1B1ESR1 | |
| SCHEMBL9643301 | 0.83 | THRA (0.41) | THRATHRBESR1S1PR2S1PR1 | |
| SCHEMBL9641652 | 0.82 | AKR1B1 (0.43) | AKR1B1LDHALDHB | |
| SCHEMBL9641747 | 0.81 | AKR1B1 (0.45) | AKR1B1LDHALDHB | |
| SCHEMBL9643120 | 0.80 | AKR1B1 (0.37) | AKR1B1LDHALDHB | |
| SCHEMBL9643555 | 0.78 | ALDH1A1 (0.44) | AKR1B1ESR1 | |
| SCHEMBL9642722 | 0.77 | MTNR1A (0.41) | THRATHRBPLA2G2A | |
| SCHEMBL9641919 | 0.75 | TOP2A (0.40) | AKR1B1 | |
| SCHEMBL9641993 | 0.75 | TOP2A (0.40) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215622-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS AND PROCESS FOR MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1992-06-17 | — | — | EP | disclosed |
| US-4946845-A | STABLE ANTIINFLAMMATORY AGENTS, LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4792556-A | LIPOXYGENASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0215622-A2 | Naphthalene anti-psoriatic agents and process for making them | SYNTEX (U.S.A.) INC. (US) | 1987-03-25 | — | — | EP | disclosed |