Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234185 | 0.77 | MCL1 (0.55) | LMNAMAPK1MEN1POLBMAPT | |
| SCHEMBL11379316 | 0.75 | LMNA (0.49) | LMNAMAPK1MEN1POLBMAPT | |
| SCHEMBL10624355 | 0.72 | LIMK1 (0.58) | LMNAMAPK1MEN1POLBMAPT | |
| SCHEMBL9642569 | 0.69 | NPC1 (0.48) | LMNAMAPK1MEN1POLBMAPT | |
| Dibenzothiophene SCHEMBL28840356 | 0.68 | GPR3 (0.58) | LMNAMAPK1MEN1POLBMAPT | |
| SCHEMBL702447 | 0.67 | TDP1 (0.61) | LMNAMAPK1MAPTRECQLNPSR1 | |
| SCHEMBL10894082 | 0.67 | TDP1 (0.61) | LMNAMAPK1MAPTRECQLNPSR1 | |
| SCHEMBL10624354 | 0.67 | PTGS2 (0.59) | LMNAMEN1KMT2APTGS2RXFP1 | |
| SCHEMBL9967691 | 0.66 | MAPT (0.51) | LMNAMAPK1MEN1POLBMAPT | |
| Dibenzothiophene SCHEMBL27494049 | 0.65 | GPR3 (0.61) | LMNAMAPK1MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147889-A | Antiinflammatory, analgesic | CIBA-GEIGY CORPORATION (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0336886-B1 | THIO COMPOUNDS | CIBA-GEIGY AG (CH) | 1992-08-26 | — | — | EP | disclosed |
| US-5051421-A | Analgesics and antiinflammatory agents | CIBA-GEIGY CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0336886-A1 | Thio compounds | CIBA-GEIGY AG (CH) | 1989-10-11 | — | — | EP | disclosed |