Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234185 | 0.82 | MCL1 (0.55) | LMNAMAPK1MCL1ALDH1A1GPR3 | |
| SCHEMBL9556945 | 0.81 | LMNA (0.49) | LMNAMAPK1MCL1ALDH1A1GPR3 | |
| SCHEMBL10624355 | 0.81 | LIMK1 (0.58) | LMNAMAPK1MCL1ALDH1A1GPR3 | |
| SCHEMBL17023642 | 0.79 | LMNA (0.47) | LMNAMAPK1MCL1ALDH1A1GPR3 | |
| SCHEMBL9641904 | 0.75 | LMNA (0.49) | LMNAMAPK1MCL1ALDH1A1ALOX15 | |
| SCHEMBL9642569 | 0.74 | NPC1 (0.48) | LMNAMAPK1MCL1ALDH1A1MEN1 | |
| SCHEMBL9601620 | 0.73 | RAB9A (0.61) | LMNAMAPK1MCL1ALDH1A1ALOX15 | |
| Dibenzothiophene SCHEMBL11884108 | 0.73 | GPR3 (0.67) | LMNAMAPK1MCL1ALDH1A1GPR3 | |
| SCHEMBL10624354 | 0.72 | PTGS2 (0.59) | LMNAMEN1KMT2AMAOBGAA | |
| SCHEMBL181822 | 0.71 | THRB (0.52) | LMNAMCL1ALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4260776-A | PYRAZOLONE | BAYER AKTIENGESELLSCHAFT (DE) | 1981-04-07 | — | — | US | disclosed |