Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093751 | 0.74 | ALOX5 (0.43) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL9645796 | 0.72 | ALOX5 (0.56) | PTGER4 | |
| SCHEMBL9644515 | 0.71 | DRD2 (0.37) | MAOAKDM4ECHRNA7KCNH2HSD17B10 | |
| SCHEMBL9644524 | 0.70 | ALOX5 (0.51) | MEN1KMT2AMAPTHSD17B10GAA | |
| SCHEMBL9645411 | 0.69 | HCAR1 (0.41) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10370364 | 0.68 | DDB1 (0.42) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL9645891 | 0.67 | GABRP (0.48) | KMT2AMAPTCHRNA7GAATSHR | |
| SCHEMBL19642427 | 0.66 | MAOA (0.55) | PTGER4MAOAMEN1KMT2AMAPT | |
| SCHEMBL3200559 | 0.66 | PTGER4 (0.48) | AHRPTGER4MAOAMEN1KMT2A | |
| SCHEMBL16442542 | 0.65 | AHR (0.50) | AHRPTGER4MAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |