Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150784 | 0.73 | ALDH1A1 (0.59) | TSPOMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL30168125 | 0.73 | ALDH1A1 (0.59) | TSPOMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL9645937 | 0.71 | ALOX5 (0.45) | FEN1 | |
| SCHEMBL17145302 | 0.69 | LMNA (0.37) | LMNAKMT2A | |
| SCHEMBL4078853 | 0.69 | GRM5 (0.64) | TSHRMEN1KMT2A | |
| SCHEMBL4196369 | 0.69 | ALDH1A1 (0.52) | TSPOFEN1MAPTSIRT1MAPK1 | |
| SCHEMBL1644965 | 0.68 | MAPK1 (0.59) | MAPTMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5101721 | 0.67 | ALDH1A1 (0.53) | TSPOMAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL9222061 | 0.67 | ALDH1A1 (0.53) | SIRT1MAPK1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL7055476 | 0.66 | ALDH1A1 (0.57) | TSPOMAPK1SMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5173496-A | Antiinflammatory agents | ICI PHARMA (FR) | 1992-12-22 | — | — | US | disclosed |
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | disclosed |
| EP-0284174-A1 | Therapeutic preparations | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-09-28 | — | — | EP | disclosed |