Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.38 |
| ▸ | AR | P10275 | 11/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 9/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407061 | 0.91 | PGR (0.37) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8407053 | 0.86 | NR3C1 (0.36) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8410268 | 0.85 | PGR (0.35) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8768021 | 0.75 | PGR (0.53) | PGRARNR3C1CYP3A4LMNA | |
| SCHEMBL8536196 | 0.75 | PGR (0.53) | PGRARNR3C1CYP3A4LMNA | |
| SCHEMBL8410185 | 0.75 | PGR (0.40) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL9146687 | 0.75 | AR (0.58) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8619892 | 0.74 | NR3C1 (0.46) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8541351 | 0.74 | PGR (0.53) | PGRARNR3C2NR3C1CYP3A4 | |
| SCHEMBL8541353 | 0.74 | PGR (0.53) | PGRARNR3C2NR3C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089488-A | Anticarcinogenic agents; treating glaucoma, hypertension, diabetes, insomia, osteoporosis | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-4814327-A | ANTIPROGESTERONE, ANTIGLUCOCORTICORD | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-03-21 | — | — | US | disclosed |