SCHEMBL965095

SCHEMBL965095

CCCCOCCCNC(=O)c1cnc(C(=O)NCC(=O)OCc2ccccc2)c(OC)c1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.48
GAA P10253 1/20 0.48
STAMBP O95630 1/20 0.46
KMT2A Q03164 6/20 0.46
MEN1 O00255 4/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TSHR P16473 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
MTNR1B P49286 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
RAB9A P51151 3/20 0.43
NPC1 O15118 2/20 0.43
PKM P14618 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GLA P06280 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5070931 0.91 STAMBP (0.44) MAPTGAASTAMBPKMT2AMEN1
SCHEMBL1509146 0.90 EGLN1 (0.49) MAPTGAASTAMBPKMT2AMEN1
SCHEMBL8784539 0.89 GAA (0.45) MAPTGAASTAMBPKMT2AMEN1
SCHEMBL966853 0.89 KMT2A (0.53) MAPTGAAKMT2AMEN1L3MBTL1
SCHEMBL5146388 0.86 SMPD1 (0.41) MAPTSTAMBPKMT2AMEN1L3MBTL1
SCHEMBL8881979 0.86 MEN1 (0.50) MAPTGAAKMT2AMEN1SMN1; SMN2
SCHEMBL8882701 0.86 MEN1 (0.50) MAPTGAAKMT2AMEN1SMN1; SMN2
SCHEMBL8880594 0.86 MEN1 (0.50) MAPTGAAKMT2AMEN1SMN1; SMN2
SCHEMBL8883714 0.86 MEN1 (0.50) MAPTGAAKMT2AMEN1SMN1; SMN2
SCHEMBL8786558 0.86 SMPD1 (0.42) MAPTGAASTAMBPKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150080425-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE FIBROGEN, INC. (US) 2015-03-19 US claimed
US-20060216295-A1 Methods of identifying therapeutic targets for the treatment of vulvovaginal atrophy WYETH (US) 2006-09-28 US claimed
WO-2006099610-A2 METHODS OF IDENTIFYING THERAPEUTIC TARGETS FOR THE TREATMENT OF VULVOVAGINAL ATROPHY WYETH (US) 2006-09-21 WO claimed
US-20240182424-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM FIBROGEN, INC. (US) 2024-06-06 US disclosed
US-11680047-B2 Enhanced erythropoiesis and iron metabolism FIBROGEN, INC. (US) 2023-06-20 US disclosed
US-11680048-B2 Enhanced erythropoiesis and iron metabolism FIBROGEN, INC. (US) 2023-06-20 US disclosed
EP-2298301-B2 MEDICAMENTS FOR TREATING ANEMIA ASSOCIATED WITH KIDNEY DISEASE FIBROGEN INC (US) 2022-11-16 EP disclosed
US-20210369702-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE FIBROGEN, INC. (US) 2021-12-02 US disclosed
US-20210114987-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM FIBROGEN, INC. 2021-04-22 US disclosed
US-20210107878-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM FIBROGEN, INC. 2021-04-15 US disclosed
US-10927081-B2 Enhanced erythropoiesis and iron metabolism FIBROGEN, INC. (US) 2021-02-23 US disclosed
US-20050020487-A1 Enhanced erythropoiesis and iron metabolism FIBROGEN, INC. 2005-01-27 US disclosed
EP-1487472-A2 STABILIZATION OF HYPOXIA INDUCIBLE FACTOR (HIF) ALPHA FIBROGEN, INC. (US) 2004-12-22 EP disclosed
WO-2004108121-A1 USE OF HIF ALPHA STABILIZERS FOR ENHANCING ERYTHROPOIESIS FIBROGEN, INC. (US) 2004-12-16 WO disclosed
EP-1463823-A2 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN, INC. (US) 2004-10-06 EP disclosed
US-20030176317-A1 Stabilization of hypoxia inducible factor (HIF) alpha FIBROGEN, INC. 2003-09-18 US disclosed
US-20030153503-A1 Methods of increasing endogenous erythropoietin (EPO) FIBROGEN, INC. 2003-08-14 US disclosed
WO-2003053997-A2 METHODS OF INCREASING ENDOGENOUS ERYTHROPOIETIN (EPO) FIBROGEN, INC. (US) 2003-07-03 WO disclosed
WO-2003049686-A2 STABILIZATION OF HYPOXIA INDUCIBLE FACTOR (HIF) ALPHA FIBROGEN, INC. (US) 2003-06-19 WO disclosed
US-5658933-A Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150080425-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE HIF1AN, HIF1A, EGLN2 MAPT 4792/4885GAA 95/4885STAMBP 3146/4885
US-20030176317-A1 Stabilization of hypoxia inducible factor (HIF) alpha HIF1A, HIF1AN, EGLN2 MAPT 3766/4885GAA 472/4885STAMBP 1937/4885
US-20060216295-A1 Methods of identifying therapeutic targets for the treatment of vulvovaginal atrophy DNASE1L3, ANXA4, SERPINA6 MAPT 4635/4885GAA 1147/4885STAMBP 3111/4885
US-11680048-B2 Enhanced erythropoiesis and iron metabolism EPOR, HAMP, TFRC MAPT 4637/4885GAA 559/4885STAMBP 3501/4885
US-11680047-B2 Enhanced erythropoiesis and iron metabolism EPOR, HAMP, TFRC MAPT 4742/4885GAA 1091/4885STAMBP 3254/4885
US-20050020487-A1 Enhanced erythropoiesis and iron metabolism EPOR, HAMP, TFRC MAPT 4637/4885GAA 559/4885STAMBP 3501/4885
US-20210369702-A1 METHODS FOR TREATING ANEMIA IN SUBJECTS HAVING KIDNEY FAILURE USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF) HYDROXYLASE HIF1AN, HIF1A, EGLN2 MAPT 4792/4885GAA 95/4885STAMBP 3146/4885
US-20240182424-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM EPOR, HAMP, TFRC MAPT 4637/4885GAA 559/4885STAMBP 3501/4885
US-20030153503-A1 Methods of increasing endogenous erythropoietin (EPO) EPOR, EGLN3, EGLN2 MAPT 4673/4885GAA 740/4885STAMBP 3859/4885
US-20210114987-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM EPOR, HAMP, TFRC MAPT 4637/4885GAA 559/4885STAMBP 3501/4885
US-20210107878-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM EPOR, HAMP, TFRC MAPT 4742/4885GAA 1091/4885STAMBP 3254/4885
US-10927081-B2 Enhanced erythropoiesis and iron metabolism EPOR, HAMP, TFRC MAPT 4637/4885GAA 559/4885STAMBP 3501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.