Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 11/20 | 0.58 |
| ▸ | XDH | P47989 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23114951 | 0.78 | XDH (0.54) | GPR84XDHHTTLMNAMEN1 | |
| SCHEMBL10369771 | 0.73 | KMT2A (0.54) | GPR84KMT2A | |
| SCHEMBL4384740 | 0.72 | XDH (0.67) | GPR84XDHHTTLMNAMEN1 | |
| SCHEMBL8535455 | 0.70 | XDH (0.67) | GPR84XDHKDM4EALDH1A1 | |
| SCHEMBL7699028 | 0.70 | GPR84 (0.54) | GPR84XDH | |
| SCHEMBL4384744 | 0.70 | XDH (1.00) | XDH | |
| SCHEMBL8535457 | 0.70 | XDH (1.00) | XDH | |
| SCHEMBL22644445 | 0.69 | ALDH1A1 (0.50) | GPR84XDHHTTLMNAMEN1 | |
| SCHEMBL15055248 | 0.69 | TLR8 (0.49) | GPR84POLBKMT2A | |
| SCHEMBL15055542 | 0.69 | TLR8 (0.49) | GPR84POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303348-B1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1992-01-08 | — | — | EP | claimed |
| US-4910204-A | Treatment of leukotriene mediated pulmonary disorders, antihistamine, cardiovascular and gastrointestinal disorders; antiinflammatory agents | PFIZER INC. (US) | 1990-03-20 | — | — | US | claimed |
| EP-0303348-A1 | 2-Amino-5-hydroxy-4-pyrimidones | PFIZER INC. (US) | 1989-02-15 | — | — | EP | claimed |
| WO-1989000423-A1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1989-01-26 | — | — | WO | claimed |
| JP-1029367-A | — | — | None | — | — | JP | disclosed |
| EP-0303348-B1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4910204-A | Treatment of leukotriene mediated pulmonary disorders, antihistamine, cardiovascular and gastrointestinal disorders; antiinflammatory agents | PFIZER INC. (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0303348-A1 | 2-Amino-5-hydroxy-4-pyrimidones | PFIZER INC. (US) | 1989-02-15 | — | — | EP | disclosed |
| WO-1989000423-A1 | 2-AMINO-5-HYDROXY-4-PYRIMIDONES | PFIZER INC. (US) | 1989-01-26 | — | — | WO | disclosed |