Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 8/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CREB1 | P16220 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656957 | 0.88 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDCYP1A2GLA | |
| SCHEMBL9657099 | 0.88 | KDM4E (0.39) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL9657016 | 0.86 | LTA4H (0.41) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL9657122 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1HPGDCYP1A2GLA | |
| SCHEMBL9656687 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL10644653 | 0.79 | CREB1 (0.37) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL9656491 | 0.77 | LTA4H (0.46) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11515576 | 0.75 | CREB1 (0.40) | KDM4EALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL9656934 | 0.74 | HPGD (0.36) | KDM4EALDH1A1HPGDCYP1A2GAA | |
| SCHEMBL9654728 | 0.74 | NR5A1 (0.50) | KDM4EALDH1A1CYP3A4CYP2C9LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |