Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657137 | 0.86 | ELANE (0.46) | ELANEMAPTKDM4ELMNAHPGD | |
| SCHEMBL9657101 | 0.86 | ELANE (0.42) | ELANEMTNR1AMTNR1BKMT2AMAPT | |
| SCHEMBL9657812 | 0.82 | ELANE (0.40) | ELANEKMT2AMAPTLMNAMEN1 | |
| SCHEMBL9659814 | 0.82 | ELANE (0.44) | ELANEKMT2AMAPTKDM4ELMNA | |
| SCHEMBL9658432 | 0.81 | LMNA (0.44) | ELANEKMT2AMAPTKDM4ELMNA | |
| SCHEMBL9657998 | 0.81 | ELANE (0.46) | ELANEMAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9658516 | 0.81 | KMT2A (0.44) | ELANEKMT2AMAPTKDM4ELMNA | |
| SCHEMBL9657026 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BMAPTKDM4E | |
| SCHEMBL9658382 | 0.80 | ELANE (0.47) | ELANEKMT2AMAPTKDM4ELMNA | |
| SCHEMBL9657605 | 0.79 | ABCB11 (0.39) | KMT2AMAPTKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |