Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | UBE2I | P63279 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665356 | 0.82 | MAPT (0.43) | L3MBTL1TP53ATMMEN1KMT2A | |
| SCHEMBL7234553 | 0.80 | ALDH1A1 (0.40) | HTTCYP2C19MEN1KMT2ATDP2 | |
| SCHEMBL7236836 | 0.80 | USP2 (0.43) | CYP2C19MEN1KMT2ATDP2CASP6 | |
| SCHEMBL9665440 | 0.79 | TP53 (0.44) | L3MBTL1TP53ATMHTTKMT2A | |
| SCHEMBL9665452 | 0.78 | MAPT (0.48) | L3MBTL1TP53ATMHTTCYP2C19 | |
| SCHEMBL9667195 | 0.77 | USP2 (0.38) | ATMMEN1KMT2ATDP2HKDC1 | |
| SCHEMBL9667871 | 0.77 | TP53 (0.44) | L3MBTL1TP53ATMHTTCYP2C19 | |
| SCHEMBL10733852 | 0.76 | PTGS2 (0.42) | L3MBTL1TP53ATMHTTMEN1 | |
| SCHEMBL10737485 | 0.73 | MEN1 (0.41) | TP53MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10738159 | 0.72 | MAPT (0.44) | TP53HTTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4644005-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1987-02-17 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |