Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 7/20 | 0.33 |
| ▸ | CASP6 | P55212 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CFTR | P13569 | 3/20 | 0.32 |
| ▸ | GOPC | Q9HD26 | 3/20 | 0.32 |
| ▸ | UBE2I | P63279 | 3/20 | 0.32 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.32 |
| ▸ | UBA2 | Q9UBT2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667266 | 0.91 | ALDH1A1 (0.40) | ALDH1A1TSHRKDM4EGAAMEN1 | |
| SCHEMBL7236836 | 0.88 | USP2 (0.43) | ALDH1A1TSHRKDM4EGAAUSP2 | |
| SCHEMBL9666424 | 0.84 | CYP19A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL9666166 | 0.80 | L3MBTL1 (0.43) | MEN1KMT2AHKDC1CASP6POLB | |
| SCHEMBL10747205 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL7234484 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TSHRKDM4EGAAUSP2 | |
| SCHEMBL9665384 | 0.74 | TDP2 (0.37) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL10741283 | 0.74 | TDP2 (0.35) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL7237207 | 0.73 | MEN1 (0.38) | ALDH1A1GAAMEN1KMT2AHKDC1 | |
| SCHEMBL7242408 | 0.71 | ALDH1A1 (0.43) | ALDH1A1TSHRKDM4EGAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030004162-A1 | Use of glycogen phosphorylase inhibitors | TREADWAY JUDITH L (US) | 2003-01-02 | — | — | US | disclosed |
| US-20020031816-A1 | METHOD OF INHIBITION OF HUMAN GLYCOGEN PHOSPHORYLASE | PFIZER PRODUCTS INC. | 2002-03-14 | — | — | US | disclosed |
| EP-1136071-A2 | Use of glycogen phosphorylase inhibitors | Pfizer Products Inc. (US) | 2001-09-26 | — | — | EP | disclosed |
| EP-0978279-A1 | Inhibitors of human glycogen phosphorylase | Pfizer Products Inc. (US) | 2000-02-09 | — | — | EP | disclosed |
| US-5998463-A | Glycogen phosphorylase inhibitors | PFIZER INC (US) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004162-A1 | Use of glycogen phosphorylase inhibitors | PYGL, PYGM, GYS2 | ALDH1A1 2056/4885TSHR 4593/4885KDM4E 2087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.