Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665452 | 0.90 | MAPT (0.48) | MAPTSMN1; SMN2L3MBTL1KMT2AMEN1 | |
| SCHEMBL9665440 | 0.88 | TP53 (0.44) | SMN1; SMN2L3MBTL1KMT2ATP53ATM | |
| SCHEMBL9667871 | 0.88 | TP53 (0.44) | MAPTL3MBTL1KMT2AMEN1HSD17B10 | |
| SCHEMBL10737485 | 0.84 | MEN1 (0.41) | MAPTSMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL9666166 | 0.82 | L3MBTL1 (0.43) | MAPTL3MBTL1KMT2AMEN1HSD17B10 | |
| SCHEMBL10738159 | 0.81 | MAPT (0.44) | MAPTSMN1; SMN2KMT2AMEN1HSD17B10 | |
| SCHEMBL10733852 | 0.79 | PTGS2 (0.42) | MAPTL3MBTL1KMT2AMEN1HSD17B10 | |
| SCHEMBL9667449 | 0.77 | MEN1 (0.46) | MAPTSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL7234484 | 0.77 | ALDH1A1 (0.45) | MAPTKMT2AMEN1GAAPOLB | |
| SCHEMBL10732971 | 0.76 | ALDH1A1 (0.42) | MAPTSMN1; SMN2L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4644005-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1987-02-17 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |