Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRK6 | P43250 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10672832 | 0.81 | LMNA (0.67) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL16137360 | 0.76 | UHRF1 (0.46) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL16123281 | 0.74 | UHRF1 (0.45) | ALOX15KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10525630 | 0.73 | ALDH1A1 (0.46) | ALOX15KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL437152 | 0.73 | ALDH1A1 (0.69) | ALOX15KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL15948525 | 0.73 | UHRF1 (0.43) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL12796841 | 0.73 | NOS2 (0.45) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL29987569 | 0.73 | ALDH1A1 (0.69) | ALOX15KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1828420 | 0.72 | HSD17B10 (0.50) | KDM4EALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL11840158 | 0.72 | ALOX15 (0.57) | ALOX15KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234980-B1 | 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-16 | — | — | EP | disclosed |
| EP-0234980-A1 | 2-Benzimidazolylalkylthio (or sulfinyl or sulfonyl) derivatives, their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-09-02 | — | — | EP | disclosed |