Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540588 | 0.79 | NQO2 (0.53) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL9668580 | 0.79 | EPHX2 (0.62) | KMT2AMEN1 | |
| SCHEMBL8677028 | 0.78 | NPC1 (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL10712905 | 0.77 | LMNA (0.64) | HTR1ADRD2LMNASGMS2GAA | |
| SCHEMBL2038509 | 0.76 | PTGER1 (0.67) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL7650855 | 0.76 | HTR1A (0.67) | HTR1ADRD2ABCB1LMNAGAA | |
| SCHEMBL6357661 | 0.75 | SGMS2 (0.52) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL5305401 | 0.75 | LMNA (0.60) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL8577017 | 0.74 | HTR1A (0.46) | HTR1ADRD2PTGER1PTGER4PTGER3 | |
| SCHEMBL3930253 | 0.74 | HTR1A (0.59) | HTR1ADRD2PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456760-A4 | LIPOXYGENASE INHIBITING COMPOUNDS | — | 1992-01-08 | — | — | EP | disclosed |
| EP-0456760-A1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-11-21 | — | — | EP | disclosed |