Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 3/20 | 0.51 |
| ▸ | TDP2 | O95551 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CASP9 | P55211 | 1/20 | 0.51 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.51 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21214242 | 0.78 | MEN1 (0.43) | KMT2AMEN1GRIA1CACNG8GAA | |
| SCHEMBL23242558 | 0.77 | CSNK1G1 (0.56) | CASP6TDP2CASP3CASP7CASP9 | |
| SCHEMBL13809406 | 0.76 | HTR5A (0.44) | KMT2AMEN1DAOCA12CA9 | |
| SCHEMBL688899 | 0.73 | GRIA1 (0.42) | CASP6TDP2CASP3CASP7CASP9 | |
| SCHEMBL6900208 | 0.73 | MAOA (0.55) | CASP6CASP3MAOAKMT2AMEN1 | |
| SCHEMBL30226461 | 0.72 | MAOA (0.42) | CASP6CASP3MAOATSHRKMT2A | |
| SCHEMBL2087698 | 0.70 | TDP2 (0.66) | CASP6TDP2CASP3CASP7CASP9 | |
| SCHEMBL422023 | 0.69 | TDP2 (1.00) | CASP6TDP2CASP3CASP7CASP9 | |
| SCHEMBL29580380 | 0.69 | TDP2 (1.00) | CASP6TDP2CASP3CASP7CASP9 | |
| SCHEMBL21000480 | 0.68 | MAOA (0.56) | CASP6TDP2CASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273401-B1 | ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-4849441-A | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0273401-A1 | Isoindolin-1-one derivative and antiarrhythmic agent | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1988-07-06 | — | — | EP | disclosed |