Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GGT1 | P19440 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291627 | 0.89 | KDM4E (0.47) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL20166759 | 0.78 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL3169148 | 0.78 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL29277820 | 0.76 | KDM4E (0.48) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| Potassium Ion SCHEMBL9114094 | 0.75 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| Lithium Ion SCHEMBL10680313 | 0.75 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL7065753 | 0.75 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL10981093 | 0.75 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL7085287 | 0.75 | KDM4E (0.42) | MAPTL3MBTL1ALDH1A1KDM4EHPGD | |
| SCHEMBL291629 | 0.75 | KDM4E (0.47) | MAPTL3MBTL1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340804-B1 | Lubricating oil compositions | INFINEUM INT LTD (GB) | 2016-11-16 | — | — | EP | disclosed |
| EP-1266955-B1 | Lubricating oil compositions | INFINEUM INT LTD (GB) | 2013-11-06 | — | — | EP | disclosed |
| EP-1512737-B1 | Lubricating oil composition for marine engines | INFINEUM INT LTD (GB) | 2011-04-20 | — | — | EP | disclosed |
| US-7867955-B2 | Lubricating oil composition | INFINEUM INTERNATIONAL LIMITED (GB) | 2011-01-11 | — | — | US | disclosed |
| US-7838470-B2 | Lubricating oil composition | INFINEUM INTERNATIONAL LIMITED (GB) | 2010-11-23 | — | — | US | disclosed |
| US-20060172896-A1 | Lubricating oil composition | INFINEUM INTERNATIONAL LIMITED (GB) | 2006-08-03 | — | — | US | disclosed |
| US-20050153848-A1 | Lubricating oil composition | BELL IAN A W (GB) | 2005-07-14 | — | — | US | disclosed |
| EP-1533362-A1 | Lubricating oil composition | Infineum International Limited (GB) | 2005-05-25 | — | — | EP | disclosed |
| US-20050070444-A1 | crankcase lubricating oil; enhanced performance ; diesel engine piston cleanliness | INFINEUM INTERNATIONAL LIMITED (GB) | 2005-03-31 | — | — | US | disclosed |
| EP-1518920-A1 | Lubricating oil composition | Infineum International Limited (GB) | 2005-03-30 | — | — | EP | disclosed |
| US-20030162674-A1 | Lubricating oil compositions | INFINEUM INTERNATIONAL LIMITED (GB) | 2003-08-28 | — | — | US | disclosed |
| US-20030134758-A1 | Compounds capable of reducing friction coefficients under mixed lubrication or boundary lubrication conditions in a heavy duty diesel engine lubricating oil composition for improving the fuel economy of a heavy duty diesel engine. | BOVINGTON CHARLES H (GB) | 2003-07-17 | — | — | US | disclosed |
| EP-1323816-A1 | Heavy duty diesel engine lubricating oil compositions | Infineum International Limited (GB) | 2003-07-02 | — | — | EP | disclosed |
| EP-1321507-A1 | Heavy duty diesel engine lubricating oil compositions | Infineum International Limited (GB) | 2003-06-25 | — | — | EP | disclosed |
| US-20030096716-A1 | Lubricating oil composition | INTFINEUM INTERNATIONAL LIMITED (GB) | 2003-05-22 | — | — | US | disclosed |
| EP-1266955-A1 | Lubricating oil compositions | Infineum International Limited (GB) | 2002-12-18 | — | — | EP | disclosed |
| EP-1262538-A2 | Anti-wear and anti-oxidant additives for lubricating oil compositions | Infineum International Limited (GB) | 2002-12-04 | — | — | EP | disclosed |
| US-20020155958-A1 | Lubrication | INFINEUM INTERNATIONAL LIMITED (GB) | 2002-10-24 | — | — | US | disclosed |
| EP-1229101-A1 | Marine diesel engine lubricant | Infineum International Limited (GB) | 2002-08-07 | — | — | EP | disclosed |
| EP-1229102-A1 | Lubricating oil composition | Infineum International LTD (GB) | 2002-08-07 | — | — | EP | disclosed |