Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672140 | 0.88 | TSHR (0.41) | TSHRMAPK1MEN1MAPTKMT2A | |
| SCHEMBL8337165 | 0.87 | TSHR (0.36) | TSHRMAPK1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9674008 | 0.85 | TYMS (0.38) | TSHRMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL9862075 | 0.82 | THRB (0.39) | TSHRMAPK1MEN1MAPTKMT2A | |
| SCHEMBL285513 | 0.81 | TSHR (0.38) | TSHRMAPK1MEN1MAPTKMT2A | |
| SCHEMBL9673871 | 0.79 | PTGS2 (0.42) | PTPN1TSHRMAPK1PTGS2NPC1 | |
| SCHEMBL9671479 | 0.78 | MAPK1 (0.46) | PTPN1TSHRMAPK1PTGS2MAPT | |
| SCHEMBL9321984 | 0.77 | ALDH1A1 (0.37) | TSHRMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL9674003 | 0.76 | TSHR (0.40) | TSHRMAPK1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9671453 | 0.76 | MAPK1 (0.44) | PTPN1TSHRMAPK1PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324431-B1 | NEW INDOLYLPIPERIDINE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-5017703-A | Antiallergens, antiinflammatory | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| US-4935432-A | ANTIALLERGENS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-06-19 | — | — | US | disclosed |
| EP-0324431-A1 | New indolylpiperidine compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-19 | — | — | EP | disclosed |