Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988622 | 0.73 | NOTUM (0.38) | NOTUMNSD2POLBGRK2CASP6 | |
| SCHEMBL16610760 | 0.66 | KDM4E (0.42) | POLBALDH1A1 | |
| 2-Carboxybenzeneacetic Acid SCHEMBL2148321 | 0.61 | BCAT2 (0.53) | CTDSP1AKR1B1ALDH1A1ALOX15CYP1A2 | |
| SCHEMBL1664457 | 0.61 | POLB (0.42) | POLBALDH1A1ALOX15 | |
| Phthalic Acid SCHEMBL23929048 | 0.59 | ALDH1A1 (0.64) | POLBALDH1A1ALOX15 | |
| Phthalic Acid SCHEMBL21332399 | 0.59 | ALDH1A1 (0.64) | POLBALDH1A1ALOX15 | |
| SCHEMBL598224 | 0.58 | CA2 (0.56) | NSD2POLBGRK2CASP6CTDSP1 | |
| Hydrochloric Acid SCHEMBL3625706 | 0.57 | CA2 (0.54) | NSD2POLBGRK2CASP6CTDSP1 | |
| Phthalic Acid SCHEMBL35170 | 0.57 | ALDH1A1 (0.58) | POLBALDH1A1ALOX15CYP1A2 | |
| SCHEMBL5060389 | 0.57 | AKR1B1 (0.56) | POLBCASP6CTDSP1AKR1B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275092-B1 | PROCESS FOR PREPARING (+)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1,7-DICARBOXYLATES | SYNTEX (U.S.A.) INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| US-4937368-A | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1990-06-26 | — | — | US | disclosed |
| US-4835288-A | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates | SYNTEX INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0275092-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1988-07-20 | — | — | EP | disclosed |