Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729436 | 0.78 | ALDH1A1 (0.36) | TDP1MMP13PKMALDH1A1MEN1 | |
| SCHEMBL9380008 | 0.76 | — | — | |
| SCHEMBL515166 | 0.76 | KMT2A (0.48) | ESR1ESR2TDP1MMP13PKM | |
| SCHEMBL9379078 | 0.75 | GABRA1 (0.45) | LMNAALDH1A1POLBMEN1MAPT | |
| SCHEMBL9676223 | 0.74 | MEN1 (0.44) | ESR1LMNAMMP13ALDH1A1POLB | |
| SCHEMBL15516157 | 0.73 | LMNA (0.57) | TP53LMNAPKMALDH1A1MEN1 | |
| SCHEMBL10587619 | 0.73 | ESR1 (0.36) | ESR1ESR2TDP1TP53PDE10A | |
| SCHEMBL10391857 | 0.73 | ESR1 (0.41) | ESR1LMNAMMP13ALDH1A1POLB | |
| SCHEMBL10392048 | 0.71 | MMP13 (0.50) | ESR1ESR2MMP13ALDH1A1MEN1 | |
| SCHEMBL10465599 | 0.71 | MMP13 (0.47) | ESR1MMP13ALDH1A1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336475-B1 | 1,6-DIAZASPIRO (4,4)NONANE-2,7-DIONE DERIVATIVES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1992-12-23 | — | — | EP | disclosed |
| EP-0336475-A1 | 1,6-diazaspiro (4,4)nonane-2,7-dione derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1989-10-11 | — | — | EP | disclosed |