Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091397 | 0.86 | HTT (0.65) | APPHTTALDH1A1HPGDTSHR | |
| SCHEMBL9092335 | 0.86 | HTT (0.65) | APPHTTALDH1A1HPGDTSHR | |
| SCHEMBL13162944 | 0.85 | HPGD (0.61) | APPHTTKDM4EALDH1A1HPGD | |
| SCHEMBL8640837 | 0.85 | NAAA (0.67) | APPHTTKDM4EALDH1A1HPGD | |
| SCHEMBL771444 | 0.85 | HTT (0.59) | APPHTTKDM4EALDH1A1HPGD | |
| SCHEMBL9628332 | 0.83 | NAAA (0.64) | APPALDH1A1TSHRGAALMNA | |
| SCHEMBL6273378 | 0.83 | HTT (0.86) | HTTHPGDTSHRLMNAKMT2A | |
| Trolamine SCHEMBL9091920 | 0.82 | HTT (0.60) | APPHTTALDH1A1HPGDTSHR | |
| SCHEMBL12964827 | 0.82 | MT-CO2 (0.55) | APPHTTKDM4EALDH1A1HPGD | |
| Trolamine SCHEMBL8963359 | 0.82 | HTT (0.60) | APPHTTALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515140-A1 | Amide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5118677-A | For treating transplant rejection, host vs. draft disease, autoimmune diseases and inflammations; antibody inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-06-02 | — | — | US | disclosed |