Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680693 | 0.82 | TDP1 (0.51) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| SCHEMBL9680634 | 0.77 | ALOX15 (0.46) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| SCHEMBL9681037 | 0.76 | KMT2A (0.47) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9679675 | 0.74 | KMT2A (0.43) | HTTALDH1A1LMNARAB9AOPRM1 | |
| SCHEMBL10628022 | 0.73 | CYP2C19 (0.58) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| Etifenin SCHEMBL487233 | 0.71 | ALOX15 (1.00) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| SCHEMBL9851048 | 0.71 | KMT2A (0.54) | TDP1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL9678877 | 0.70 | TDP1 (0.58) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| SCHEMBL11130240 | 0.70 | TSHR (0.77) | CYP2C19ALOX15TSHRHIF1ATDP1 | |
| SCHEMBL9680185 | 0.70 | LMNA (0.50) | CYP2C19ALOX15TDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1050376-A | Acyl-CoA: cholesterol acyltransferase inhibitor | WARBER LAMBERT CO (US) | 1991-04-03 | — | — | CN | claimed |
| US-5153226-A | Administering as anticholesterol agents, for atherosclerosis | WARNER-LAMBERT COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| CN-1050376-A | Acyl-CoA: cholesterol acyltransferase inhibitor | WARBER LAMBERT CO (US) | 1991-04-03 | — | — | CN | disclosed |