Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MITF | O75030 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345303 | 0.78 | ALDH1A1 (1.00) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL9640442 | 0.78 | NPC1 (0.70) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL3159839 | 0.77 | NLRP3 (0.41) | ALDH1A1RAB9AKMT2ANPSR1POLB | |
| SCHEMBL9723545 | 0.73 | NPSR1 (0.47) | ALDH1A1NPC1KMT2ANPSR1LMNA | |
| SCHEMBL7339289 | 0.72 | RAB9A (0.79) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL11417909 | 0.72 | HTT (0.44) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL11142269 | 0.71 | SMN1; SMN2 (0.41) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL28665552 | 0.71 | ALDH1A1 (0.64) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL7165377 | 0.71 | NPC1 (0.58) | ALDH1A1NPC1RAB9AKMT2AHTT | |
| SCHEMBL11872903 | 0.71 | SMN1; SMN2 (0.43) | ALDH1A1NPC1RAB9AKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153226-A | Administering as anticholesterol agents, for atherosclerosis | WARNER-LAMBERT COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0415413-A1 | Acat inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |