Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 5/20 | 0.57 |
| ▸ | MMP2 | P08253 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678883 | 0.82 | MMP9 (0.56) | MMP9MMP2TDP1NPY5RTHRB | |
| SCHEMBL13957019 | 0.81 | MMP9 (0.66) | MMP9MMP2TDP1NPY5RTHRB | |
| SCHEMBL9679311 | 0.80 | SOAT2 (0.59) | MMP9SMN1; SMN2 | |
| SCHEMBL9679315 | 0.80 | SOAT2 (0.59) | MMP9SMN1; SMN2 | |
| SCHEMBL697476 | 0.80 | MMP2 (0.79) | MMP9MMP2TDP1ADAMTS4CTSL | |
| SCHEMBL1203540 | 0.80 | MMP2 (0.79) | MMP9MMP2TDP1ADAMTS4CTSL | |
| SCHEMBL697477 | 0.80 | MMP2 (0.79) | MMP9MMP2TDP1ADAMTS4CTSL | |
| SCHEMBL15213296 | 0.79 | MMP9 (0.63) | MMP9MMP2TDP1ADAMTS4CTSL | |
| SCHEMBL14519991 | 0.79 | MMP9 (0.63) | MMP9MMP2TDP1ADAMTS4CTSL | |
| SCHEMBL14544569 | 0.79 | MMP9 (0.65) | MMP9MMP2TDP1ADAMTS4CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415413-A1 | Acat inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-06 | — | — | EP | claimed |
| US-5153226-A | Administering as anticholesterol agents, for atherosclerosis | WARNER-LAMBERT COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0415413-A1 | Acat inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |