Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.64 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681853 | 0.87 | KMT2A (0.51) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6367155 | 0.82 | TOP1 (0.69) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11524597 | 0.79 | TOP1 (0.66) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2176042 | 0.79 | KDM4E (0.50) | KMT2AMAPTSMN1; SMN2HSD17B10GAA | |
| SCHEMBL12827331 | 0.78 | TOP1 (1.00) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL31517375 | 0.77 | KMT2A (0.68) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2712997 | 0.77 | TOP1 (0.62) | TOP1PTGESKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5652996 | 0.76 | L3MBTL1 (0.51) | TOP1KMT2ASMN1; SMN2MEN1NPSR1 | |
| SCHEMBL725404 | 0.75 | KMT2A (0.76) | TOP1KMT2AMAPTSMN1; SMN2SLC6A3 | |
| SCHEMBL29445347 | 0.75 | TYMS (0.57) | TOP1PTGESKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153335-A | Reacting halophthalic anhydride and alkali metal salt with acid or acid derivative catalyst | OCCIDENTAL CHEMICAL CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0460687-A2 | Process for the preparation of oxydiphthalic anhydride and acyloxyphthalic anhydrides | OCCIDENTAL CHEMICAL CORPORATION (US) | 1991-12-11 | — | — | EP | disclosed |
| US-4147706-A | Intermediates for polycyclic quinonoid antibiotics | RESEARCH CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |
| US-4070382-A | DAUNOMYCINS, ANTITUMOR AGENTS | RESEARCH CORPORATION (US) | 1978-01-24 | — | — | US | disclosed |