Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.42 |
| ▸ | NT5E | P21589 | 3/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682463 | 0.84 | HINT1 (0.42) | HINT1ADORA3ADORA1ADORA2BADORA2A | |
| SCHEMBL8531895 | 0.82 | ALDH1A1 (0.57) | HINT1ADORA3ADORA1CYP2C19ADORA2B | |
| SCHEMBL9683203 | 0.82 | P2RY1 (0.40) | HINT1NT5E | |
| SCHEMBL9683196 | 0.82 | P2RY1 (0.40) | HINT1NT5E | |
| SCHEMBL9680659 | 0.80 | PNP (0.37) | HINT1ADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL8529428 | 0.80 | HINT1 (0.61) | HINT1ADORA3ADORA1CYP2C19ADORA2B | |
| SCHEMBL8530562 | 0.80 | HINT1 (0.62) | HINT1ADORA3ADORA1CYP2C19ADORA2B | |
| SCHEMBL6881900 | 0.79 | SLC29A1 (0.48) | ADORA3ADORA1ADORA2BADORA2ASLC29A1 | |
| SCHEMBL9681406 | 0.79 | HINT1 (0.42) | HINT1ADORA3ADORA1ADORA2BNT5E | |
| SCHEMBL8532886 | 0.78 | HINT1 (0.61) | HINT1ADORA3ADORA1CYP2C19ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153318-A | Viricides for hepatitis and human t-cell leukemia/lymphoma viruses | BURROUGHS WELLCOME CO. (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0421739-A1 | 3'-azido purine nucleoside | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-04-10 | — | — | EP | disclosed |