Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683456 | 0.88 | CTSG (0.42) | TBXA2RTRAP1HSP90B1AKR1A1AKR1B1 | |
| SCHEMBL9701302 | 0.87 | PTGDR2 (0.45) | PTGDR2MAPTTBXA2RTRAP1HSP90B1 | |
| SCHEMBL9681413 | 0.75 | TBXA2R (0.41) | MAPTTBXA2RTRAP1HSP90B1ALOX5AP | |
| SCHEMBL9701533 | 0.74 | CTSG (0.42) | MAPTTBXA2RTRAP1HSP90B1AKR1A1 | |
| SCHEMBL16334449 | 0.70 | CYP1A2 (0.40) | PTGDR2MAPTALDH1A1 | |
| SCHEMBL30350667 | 0.70 | CYP1A2 (0.40) | PTGDR2MAPTALDH1A1 | |
| SCHEMBL9581575 | 0.70 | TBXA2R (0.58) | PTGDR2TBXA2R | |
| SCHEMBL9682042 | 0.70 | PTGDR2 (0.53) | PTGDR2TBXA2RALDH1A1 | |
| SCHEMBL9699191 | 0.70 | PTGDR2 (0.66) | PTGDR2TBXA2R | |
| SCHEMBL7033870 | 0.68 | PTGDR2 (0.54) | PTGDR2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |