Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681428 | 0.86 | PTGDR2 (0.71) | PTGDR2DRD2TBXA2RL3MBTL1 | |
| SCHEMBL9681251 | 0.86 | L3MBTL1 (0.53) | PTGDR2DRD2TBXA2RSLC22A12L3MBTL1 | |
| SCHEMBL9700228 | 0.86 | ALDH1A1 (0.60) | PTGDR2TBXA2RALDH1A1ATM | |
| SCHEMBL9581575 | 0.79 | TBXA2R (0.58) | PTGDR2DRD2TBXA2RNPSR1 | |
| SCHEMBL9771980 | 0.77 | P2RX3 (0.43) | PTGDR2ALDH1A1P2RX3L3MBTL1NPSR1 | |
| SCHEMBL9699174 | 0.77 | PTGDR2 (0.55) | PTGDR2DRD2TBXA2RALDH1A1P2RX3 | |
| SCHEMBL9682472 | 0.77 | TBXA2R (0.57) | PTGDR2DRD2TBXA2R | |
| SCHEMBL9699191 | 0.75 | PTGDR2 (0.66) | PTGDR2DRD2TBXA2RL3MBTL1NPSR1 | |
| SCHEMBL9683101 | 0.74 | TBXA2R (0.56) | TBXA2RP2RX3 | |
| SCHEMBL10386971 | 0.72 | ALDH1A1 (0.57) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |