Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683479 | 0.86 | AKR1B1 (0.43) | AKR1B1AKR1A1KDM1AADRA2BALDH1A1 | |
| SCHEMBL9681871 | 0.80 | MAPT (0.43) | HDAC1ALDH1A1MAPT | |
| SCHEMBL9682000 | 0.77 | MAPT (0.51) | ALDH1A1MAPT | |
| SCHEMBL25828139 | 0.76 | PTGER4 (0.56) | ALDH1A1MAPTKDM4E | |
| SCHEMBL10487973 | 0.74 | AKR1B1 (0.57) | AKR1B1AKR1A1 | |
| SCHEMBL9683520 | 0.74 | TRPM5 (0.43) | HDAC1AKR1B1ADRA2BALDH1A1 | |
| SCHEMBL5180846 | 0.73 | MEN1 (0.53) | NTRK1ADRA2BALDH1A1MAPTKDM4E | |
| SCHEMBL11158402 | 0.72 | KDM1A (0.48) | AKR1B1AKR1A1KDM1AHSP90B1TRAP1 | |
| SCHEMBL5537895 | 0.72 | KDM1A (0.46) | AKR1B1KDM1AALDH1A1 | |
| SCHEMBL12658350 | 0.71 | SHMT2 (0.48) | HDAC1ALDH1A1MAPTAURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |