Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681247 | 0.88 | ENPP2 (0.46) | RXFP1TBXA2RDRD2NPSR1MAPT | |
| SCHEMBL9681424 | 0.86 | TBXA2R (0.59) | TBXA2RDRD2MAPTTP53RAB9A | |
| SCHEMBL9700220 | 0.85 | MAPT (0.56) | TBXA2RMAPTENPP2TP53KMT2A | |
| SCHEMBL9581584 | 0.78 | TBXA2R (0.64) | TBXA2RAGTR1AGTR2 | |
| SCHEMBL9771980 | 0.78 | P2RX3 (0.43) | NPSR1MAPTPTGDR2KMT2ANPC1 | |
| SCHEMBL9683101 | 0.77 | TBXA2R (0.56) | TBXA2RTP53 | |
| SCHEMBL9699186 | 0.74 | TP53 (0.54) | TBXA2RDRD2NPSR1MAPTTP53 | |
| SCHEMBL9682469 | 0.73 | TBXA2R (0.62) | TBXA2RAGTR1AGTR2 | |
| SCHEMBL9699171 | 0.73 | AGTR1 (0.59) | TBXA2RDRD2MAPTTP53AGTR1 | |
| SCHEMBL9683183 | 0.72 | MAPT (0.62) | TBXA2RDRD2NPSR1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |