Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680365 | 0.85 | PBRM1 (0.35) | KDM4EALDH1A1CYP1A2HPGDKMT2A | |
| SCHEMBL9680412 | 0.85 | KMT2A (0.34) | KDM4EALDH1A1HPGDKMT2APDGFRB | |
| SCHEMBL9682834 | 0.82 | PDPK1 (0.39) | DAO | |
| SCHEMBL9680947 | 0.79 | PDPK1 (0.43) | KDM4EKMT2AMEN1GAARARA | |
| SCHEMBL9132454 | 0.78 | IGF1R (0.46) | TNKS | |
| SCHEMBL9680374 | 0.77 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8554186 | 0.75 | ATM (0.44) | ALDH1A1HPGDNPC1RAB9AATM | |
| SCHEMBL9680897 | 0.71 | ALDH1A1 (0.43) | KDM4EALDH1A1CYP1A2HPGDKMT2A | |
| SCHEMBL8088499 | 0.65 | TP53 (0.34) | CYP1A2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10651368 | 0.64 | PSEN1 (0.40) | RARARARBRARGPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |