Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23163017 | 0.87 | CHRM2 (0.31) | CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2398896 | 0.81 | TSHR (0.36) | MAPTCHRM5CHRM1CHRM3BLM | |
| SCHEMBL6559959 | 0.79 | TSHR (0.37) | MAPTCHRM5CHRM1CHRM3BLM | |
| SCHEMBL4613185 | 0.78 | HCAR2 (0.32) | CHRM1CHRM3ACHE | |
| SCHEMBL4613181 | 0.78 | HCAR2 (0.32) | CHRM1CHRM3ACHE | |
| SCHEMBL26914697 | 0.75 | ATM (0.38) | MAPTLMNA | |
| SCHEMBL21802631 | 0.75 | MEN1 (0.32) | — | |
| SCHEMBL11455121 | 0.74 | GPR84 (0.40) | MAPT | |
| SCHEMBL182377 | 0.74 | TSHR (0.39) | — | |
| SCHEMBL182379 | 0.74 | TSHR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132383-A | Salt formation by reacting halohydroxypropyl methacrylate mixtures with trialkylamine; addition polymerization; flocculants | POLYPURE, INC. (US) | 1992-07-21 | — | — | US | disclosed |