Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.57 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.57 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.57 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9682253 | 1.00 | DRD2 (0.57) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9378097 | 0.92 | DRD2 (0.62) | DRD2HTR2AHTR2CACHESLC6A4 | |
| SCHEMBL9383070 | 0.92 | DRD2 (0.62) | DRD2HTR2AHTR2CACHESLC6A4 | |
| Fumaric Acid SCHEMBL9683252 | 0.86 | HTR2A (0.73) | DRD2HTR2AHTR2C | |
| Fumaric Acid SCHEMBL9735299 | 0.86 | HTR2A (0.73) | DRD2HTR2AHTR2C | |
| SCHEMBL467202 | 0.84 | DRD2 (0.66) | DRD2HTR2AHTR2CACHESLC6A4 | |
| Fumaric Acid SCHEMBL1545969 | 0.83 | ACHE (0.61) | DRD2HTR2AACHESLC6A4 | |
| Fumaric Acid SCHEMBL1545971 | 0.83 | ACHE (0.61) | DRD2HTR2AACHESLC6A4 | |
| Fumaric Acid SCHEMBL1545314 | 0.82 | ACHE (0.76) | DRD2HTR2AACHESLC6A4 | |
| Fumaric Acid SCHEMBL1545316 | 0.82 | ACHE (0.76) | DRD2HTR2AACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134147-A | Antipsychotic agents | ADIR ET COMPAGNIE (FR) | 1992-07-28 | — | — | US | disclosed |
| US-5100902-A | Dopamine and Serotonin Antagonists, Antipsychotic Agents | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |