Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.51 |
| ▸ | HTR3B | O95264 | 4/20 | 0.51 |
| ▸ | HTR3A | P46098 | 4/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KHK | P50053 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681250 | 0.86 | HTR1A (0.60) | LMNAMAPTALDH1A1HTR1ASIGMAR1 | |
| SCHEMBL9680636 | 0.85 | SMO (0.50) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL9681419 | 0.84 | KDM4E (0.49) | LMNAMAPTKDM4EALDH1A1HTR3E | |
| SCHEMBL9680605 | 0.84 | DRD2 (0.57) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL9680621 | 0.83 | KHK (0.44) | DRD4LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL9682466 | 0.83 | DRD3 (0.47) | DRD4LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL9681924 | 0.83 | HTR1A (0.47) | LMNAMAPTKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL9680620 | 0.82 | HTR1A (0.47) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6125292 | 0.81 | KHK (0.56) | KDM4EALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL9681353 | 0.81 | KHK (0.42) | LMNAMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |